Skeptoid is a weekly science podcast dedicated to furthering knowledge by blasting away the widespread pseudosciences that infect popular culture.
The podcasts are fairly short (around 10 minutes) but the subject matter is always interesting, and Brian Dunning is highly entertaining, as long as you appreciate that sort of dry sarcasm (which I do)
The Atheist Experience
The Atheist Experience is a weekly cable access television show in Austin, Texas geared at a non-atheist audience. Every week we field live calls from atheists and believers alike, and you never know what you're going to get! Sometimes it can get quite feisty indeed! You don't want to miss it.
Point of Inquiry
Point of Inquiry is the premiere podcast of the Center for Inquiry, drawing on CFI's relationship with the leading minds of the day including Nobel Prize-winning scientists, public intellectuals, social critics and thinkers, and renowned entertainers. Each episode combines incisive interviews, features and commentary focusing on CFI’s issues: religion, human values and the borderlands of science.
Purpose Centered Life
Podcast by Eric Maisel, author of The Atheist's Way: Living Well Without Gods
The Skeptics Guide to the Universe
The Skeptics Guide to the Universe is a weekly Science podcast produced by the New England Skeptical Society (NESS) in association with the James Randi Educational Foundation (JREF) : discussing the latest news and topics from the world of the paranormal, fringe science, and controversial claims from a scientific point of view.
Our podcast is here to bring you relevant, under reported current events, as well as in-depth discussions from a scientific, critical, skeptical, and humorous point of view.
In our travels we will tackle the beasts of pseudo science; the paranormal, supernatural, ufo / alien encounters, misunderstood history, astronomy, space, and overwrought legends - urban or otherwise. Welcome to Skepticality, truth in podcasting.
Pat Condell's Godless Comedy
We provide detailed counter-points to the fallacious logic and blatant misinformation used by religious apologists when attempting to discredit skepticism and provide rational arguments for their dogmas. We also defend the sufficiency of reason, science and naturalistic philosophies to provide a satisfactory and morally compelling understanding of the cosmos, human nature, art and culture (so I guess you could say were also engaged in our own "naturalistic apologetic"). We try to do this all with fair-mindedness and humor.
All of these are available on the site linked, or in the iTunes Music store for free. I prefer subscribing through iTunes, since it automatically notifies me when there's a new episode, plus I can take it with my on my iPod if I want to listen in the car, while exercising, or anywhere away from my computer.